Choying Drolma was born in Kathmandu, Nepal, to Tibetan refugee parents in 1971. Her education and spiritual training were supervised by the renowned meditation master, Tulku Urgyen Rinpoche. She was well-trained in Buddhist meditation, chants, rituals, and ceremonies performance and was quickly advanced to the position of chanting master in the nunnery.
Her singing talent was first discovered by the American guitarist Steve Tibbetts during his visit to Nagi Gompa. Thanks to Tibbetts' effors, Ani Choying Drolma’s first album, Cho, was released in 1997. Since then, she has became a well-known name in the international world music scene. She toured in America and Europe and successfully presented Buddhist mantra and ritual chanting music to the world. To date, she has released 16 albums and performed at hundreds of events around world. It is said that Ani Choying Drolma’s music is like "a beam of light that cuts through the darkness and is filled with compassion and purity". Her voice has been described as “the heavenly voice' with healing power". In 2014, she was appointed the first UNICEF National Goodwill Ambassador for Nepal.